Bpsbioscience/Celastrol/27702-2/50 mg

来自 : 发布时间：2024-05-15

MW: 450.6 Da CAS Registry #: 34157-83-0 Formula: C29H38O4 Description:Celastrol is a naturally occurring triterpenoid antioxidant compound with anti-inflammatory activity. Inhibits NFkappaB (IC50 = 270 nM). It induces heat shock response and cytoprotection in various cells. Celastrol inhibits 20S proteasome chymotrypsin-like activity (IC50 = 2.5 μM). Cell permeable. Synonym(s): Tripterine Purity: >98% by TLC. Solubility: Soluble in DMSO (45 mg/ml) or Ethanol (30 mg/ml) Format: Red powder Storage / Stability:

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.

Application(s): Useful for inhibition of NF-kappa-B-dependent pathways and inhibition of 20S proteasome chymotrypsin-like activity. Reference(s): 1. Sethi, G., et al. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. Blood, 2007, 109:2727. 2. Westerheide, S.D. et al. Celastrols as inducers of the heat shock response and cytoprotection. J. Biol. Chem. 2004. 279:56053.3. Kiaei, M., et al. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener. Dis. 2005, 2:246. Warning(s): Protect from light. Protect from moisture. Avoid freeze/thaw cycles. Scientific Category: Ubiquitin Enzymes Product Type: Inhibitors/Activators Data shown is lot-specific. Contact us for specific information on other lots.