Bpsbioscience/ULK1，标志标签/40099/10µg
商品编号：
40099
品牌：
bpsbioscience
市场价：
¥8100.00
美元价：
4860.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:FreeStyle293-Fcells
MW:113kDa
Genbank#:NM_003565
Tag(s):N-terminalFLAG-tag
a.a:2–end
Background:
TheULK1protein isaserine/threonineproteinkinasethatplayscriticalroleduringinitialstagesofautophagywhichisavitalresponsetonutrientstarvation.TheconservedC-terminaldomain(CTD)ofULK1controlstheregulatoryfunctionandlocalizationoftheprotein.KnockdownofULK1inhibitstheautophagicresponseaswellasinhibitingrapamycin-inducedautophagyconsistentwitharoledownstreamofmTOR.ULK1formsacomplexwithFIP200andATG13andthiscomplexisessentialforstarvation-inducedautophagy.BothFIP200andATG13arecriticalforcorrectlocalizationofULK1tothepre-autophagosomeandstABIlityofULK1protein.ULK1isphosphorylatedbythemTORpathwayinanutrientstarvation-regulatedmanner.
Description:
Synonym(s):
ATG1,UNC51,Unc51.1,FLJ38455,Unc-51-LikeKinase,Autophagy-RelatedProtein1,HumanULK1,Ulk1,ULK1Protein
Formulation:
25mMTris-HCl,pH7.5,100mMNaCl,0.05%Tween-20,100µg/mlFLAGpeptide,20%glyceroland3mMDTT.
Format:
Aqueousbuffersolution
Storage/Stability:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.GanleyI.G.etal.,J.Biol.Chem.284(18),12297-12305(2009).
2.ChanE.Y.etal.,Mol.Cell.Biol.29(1),157-171(2009).
3.ULK1inducesautophagybyphosphorylatingBeclin-1andactivatingVPS34lipidkinase(2013)
4.AMPKandmTORregulateautophagythroughdirectphosphorylationofUlk1(2013)
5..mTORinhibitsautophagybycontrollingULK1ubiquitylation,self-associationandfunctionthroughAMBRA1andTRAF6(2013)
2.ChanE.Y.etal.,Mol.Cell.Biol.29(1),157-171(2009).
3.ULK1inducesautophagybyphosphorylatingBeclin-1andactivatingVPS34lipidkinase(2013)
4.AMPKandmTORregulateautophagythroughdirectphosphorylationofUlk1(2013)
5..mTORinhibitsautophagybycontrollingULK1ubiquitylation,self-associationandfunctionthroughAMBRA1andTRAF6(2013)
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
