CD155/TCRActivator-CHOcellline(BPSCat.#60548)
Assaymedium:ThawMedium2(BPSCat.#60184):RPMI1640+10%FBS+1%Penicillin/Streptomycin
Anti-TIGITneutralizingantibody(BPSCat.#71340)
96-welltissueculture-treatedwhiteclear-bottomassayplate
One-Stepluciferaseassaysystem(BPSCat.#60690)orotherluciferasereagentsformeasuringfireflyluciferaseactivity
Luminometer

1.LiMet.al(2014)T-cellImmunoglobulinandITIMDomain(TIGIT)Receptor/PoliovirusReceptor(PVR)LigandEngagementSuppressesInterferon-gProductionofNaturalKillerCellsviab-arrestin2-mediatedNegativeSignaling.JBiolChem.289:17647-17657.
2.StanietskyN.et.al.(2009)TheinteractionofTIGITwithPVRandPVRL2inhibitshumanNKcellcytotoxicity.PNAS.106:17858-17863.
3.Zhuet.al.(2016)IdentificationofCD112RasanovelcheckpointforhumanTcells.JExp.Med.213:167-176.
4.YuX.et.al.(2008)ThesurfaceproteinTIGITsuppressesTcellactivationbypromotingthegenerationofmatureimmunoregulatorydendriticcells.Nat.Immunol.10:48-57.

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