Bpsbioscience/ROR2, GST-tag/40296/10 µg
商品编号：
40296
品牌：
bpsbioscience
市场价：
¥7800.00
美元价：
4680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:86kDa
Genbank#:NM_004560
Tag(s):N-terminalGST-tag
a.a:427–end
Background:
ROR2isareceptorproteintyrosinekinaseandtypeItransmembraneproteinthatbelongstotheRORsubfamilyofcellsurfacereceptors.ROR2isselectivelyexpressedinthechondrocytesofalldevelopingcartilageanlagen,whereitisessentialduringinitialgrowthandpatterning,aswellassubsequentlyintheproliferatingchondrocytesofmaturegrowthplates,whereitisrequiredfornormalexpansion(1).Thus,ROR2isselectivelyexpressedinandparticularlyimportantforthechondrocytelineageandlossofROR2leadstoprofoundskeletalabnormalities(2).
Description:
RecombinanthumanROR2(a.a.427-end),withN-terminalGST-tag,expressedbySf9insectcellsviaabaculovirusexpressionsystem.
Synonym(s):
BDB,BDB1,NTRKR2,MGC163394
Purity:
≥80%
SpecificActivity:
0.17pmol/min/µg
AssayConditions:
5mMMOPS,2.5mMβ-glycerophosphate,5mMMgCl2,1mMEGTA,0.4mMEDTA,0.05mMDTT,2mMATP.IncubateROR2with0.25mg/mlMyelinBasicProteinsubstrateand50µM[33P]-ATPat30°Cfor15minutes,thenspotreactiononphosphocellulosepaper,fixin1%phosphoricacid,andassaywithascintillationcounter.
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.DeChiara,T.M.etal:Ror2,encodingareceptor-liketyrosinekinase,isrequiredforcartilageandgrowthplatedevelopment.NatureGenet.24:271-274,2000.
2.Nomi,M.etal:LossofmRor1enhancestheheartandskeletalabnormalitiesinmRor2-deficientmice:redundantandpleiotropicfunctionsofmRor1andmRor2receptortyrosinekinases.Molec.Cell.Biol.21:8329-8335,2001.
2.Nomi,M.etal:LossofmRor1enhancestheheartandskeletalabnormalitiesinmRor2-deficientmice:redundantandpleiotropicfunctionsofmRor1andmRor2receptortyrosinekinases.Molec.Cell.Biol.21:8329-8335,2001.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/ReceptorTyrosine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
