Bpsbioscience/Sestrin 1, FLAG-tag/50284/50 µg
商品编号：
50284
品牌：
bpsbioscience
市场价：
¥8500.00
美元价：
5100.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species: Human
Host Species: Sf9 insect cells
MW: 65 kDa
Genbank #: NM_014454
Tag(s): N-terminal FLAG-tag
a.a: 2–551(end)
Background:
Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. Sestrin 1 mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mTOR protein. Sestrin 1 in important for antioxidant defense because it regenerates overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation.
Description:
Human Sestrin1, also known as p53-regulated protein PA26 (GenBank Accession No. NM_014454), full length, a.a. 2-551(end), with N-terminal FLAG-tag, MW=65 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
UniProt
Q9Y6P5
Synonym(s):
Sestrin-1, PA26, SEST1, P53-Regulated Protein PA26
Formulation:
45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 3 mM DTT, 90 ?g/ml FLAG peptide and 10% glycerol
Format:
Aqueous buffer solution
Storage / Stability:
>6 months at -80°C
Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):
1. Lee, J.H., et al. (2010). Science 327(5970): 1223-8.
2. Broderick, G., et al., (2006). Pharmacogenomics 7(3): 407-419.
3. Budanov AV, Karin M. (2008). Cell 134 (3): 451-460.
4. Hay, N. (2008). Cell Metab. 8(3):184-5.
2. Broderick, G., et al., (2006). Pharmacogenomics 7(3): 407-419.
3. Budanov AV, Karin M. (2008). Cell 134 (3): 451-460.
4. Hay, N. (2008). Cell Metab. 8(3):184-5.
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Immunotherapy
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
