Bpsbioscience/小鼠MEK1（EE），GST标签/40121/10µg
商品编号：
40121
品牌：
bpsbioscience
市场价：
¥7800.00
美元价：
4680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Mouse
HostSpecies:E.coli
MW:69kDa
Genbank#:NM_008927
Tag(s):N-terminalGST-tag
a.a:fulllength
Background:
MEK1(EE)isamemberofthedualspecificityproteinkinasefamilythatactsasamitogen-activatedproteinkinase(MAPK)kinase.MEK1liesupstreamofMAPK/ERKandstimulatestheenzymaticactivityofMAPK/ERKuponawidevarietyofextra-andintracellularsignals.AsanessentialcomponentofMAPK/ERKsignaltransductionpathway,MEK1isinvolvedinmanycellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment(1).ConstitutiveactivationofMEK1resultsincellulartransformation.Thus,MEK1representsalikelytargetforpharmacologicinterventioninproliferativediseasesuchascancer(2).
Description:
RecombinantmouseMEK1(S218E,S222E),fulllengthwithSerinetoGlutamicacidmutationsona.a.218and222andanN-terminalGST-tag,expressedinE.colicells.
Synonym(s):
MAP2K1;MKK1;MAPKK1;PRKMK1;mitogenactivatedproteinkinasekinase
Purity:
≥95%
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Seger,R.etal:TheMAPKsignalingcascade.FASEBJ.9:726-735,1995.
2.Sebolt-Leopold,JS.etal:BlockadeoftheMAPkinasepathwaysuppressesgrowthofcolontumorsinvivo.NatureMed.5:810-816,1999.
2.Sebolt-Leopold,JS.etal:BlockadeoftheMAPkinasepathwaysuppressesgrowthofcolontumorsinvivo.NatureMed.5:810-816,1999.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Dual
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
