Bpsbioscience/小鼠EPHB1，GST标签/40199/10µg
商品编号：
40199
品牌：
bpsbioscience
市场价：
¥7800.00
美元价：
4680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Mouse
HostSpecies:Sf9insectcells
MW:62kDa
Genbank#:NM_173447
Tag(s):N-terminalGST-tag
a.a:591–end
Background:
EPHB1isamemberoftheEphfamilyofreceptortyrosinekinases.Ligand-activatedEPHB1formsasignalingcomplexwithNck,paxillin,andfocaladhesionkinaseandinducestyrosinephosphorylationofpaxillininac-Src-dependentmannertopromotecellmigration(1).Inaddition,activatedEPHB1recruitstheadaptorproteinsGrb2andp52Shcandpromotesp52Shcandc-SrctyrosinephosphorylationaswellasMAPK/extracellularsignal-regulatedkinase(ERK)activation.Expressionofdominant-negativec-SrcsignificantlyreducedEPHB1-dependentERK1/2activationandchemotaxis(2).
Description:
RecombinantmouseEPHB1(a.a.591-end),withN-terminalGST-tag,expressedbySf9insectcellsviaabaculovirusexpressionsystem.
Synonym(s):
Elk,Net,Cek6,Elkh,Hek6,EPHT2,AW488255,9330129L11,EphrinTypeBReceptor2
Purity:
≥90%
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Vindis,C.etal:EphB1-mediatedcellmigrationrequiresthephosphorylationofpaxillinatTyr-31/Tyr-118.JBiolChem.2004Jul2;279(27):27965-70.
2.Vindis,C.etal:EphB1recruitsc-Srcandp52ShctoactivateMAPK/ERKandpromotechemotaxis.JCellBiol.2003Aug18;162(4):661-71.
2.Vindis,C.etal:EphB1recruitsc-Srcandp52ShctoactivateMAPK/ERKandpromotechemotaxis.JCellBiol.2003Aug18;162(4):661-71.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/ReceptorTyrosine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
