Bpsbioscience/MEKK3, GST-tag/40124/10 µg
商品编号：
40124
品牌：
bpsbioscience
市场价：
¥7800.00
美元价：
4680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:105kDa
Genbank#:NM_002401
Tag(s):N-terminalGST-tag
a.a:fulllength
Background:
MEKK3isamemberoftheMEKKfamilyofproteinkinasesthatdirectlyregulateSAPKandERKpathwaybutnotthep38pathway.MEKK3modulatesSAPKandERKactivitybyactivatingtheupstreamtargetsSEKandMEK1/2,respectively(1).KSR2canregulatetheactivityofMEKK3andcanreduceMEKK3-mediatedERKactivation.KnockoutoftheMEKK3geneinmiceleadstodisruptionofbloodvesseldevelopmentandthestructuralintegrityoftheyolksac(2).TheblockageofangiogenesisinthesemiceisnotaresultofdecreasedVEGF1expressionbutratherduetoanintrinsicdefectinMekk3-/-endothelialcells.Thus,MEKK3isnecessaryforbloodvesseldevelopmentandmaybeapossIBLetargetfordrugsthatcontrolangiogenesis.
Description:
RecombinanthumanMEKK3,fulllength,withN-terminalGST-tag,expressedinSf9insectcellsviaabaculovirusexpressionsystem.
Synonym(s):
MAP3K3,MAPKKK3;mitogenactivatedproteinkinasekinase3
Purity:
≥75%
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
Ellinger-Ziegelbauer,H.Etal:Directactivationofthestress-activatedproteinkinase(SAPK)andextracellularsignal-regulatedproteinkinase(ERK)pathwaysbyaninduciblemitogen-activatedproteinkinase/ERKkinasekinase3(MEKK)derivative.J.Biol.Chem.272:2668-2674,1997.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
