Bpsbioscience/MARK3, GST-tag/40120/10 µg
商品编号：
40120
品牌：
bpsbioscience
市场价：
¥7800.00
美元价：
4680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:110kDa
Genbank#:NM_002376
Tag(s):N-terminalGST-tag
a.a:fulllength
Background:
Microtubuleaffinity-regulatingkinase3(MARK3)isamemberofthePAR-1/MARKkinasefamilywhichplaycriticalrolesinpolarityandcellcyclecontrolandareregulatedby14-3-3scaffoldingproteins,aswellastheLKB1tumoursuppressorkinaseandatypicalproteinkinaseC(PKC)(1).MARK3isadual-specificityproteinkinasethatcontrolsentryintomitosisbydephosphorylatingCDC2.MARK3seemstobeapositiveregulatorofthebeta-cateninpathwayandaninhibitoroftheJNKpathway.MARK3,aregulatorofpolarity,isalsoamodulatorofWnt-beta-cateninsignalling,indicatingalinkbetweentwoimportantdevelopmentalpathways(2).
Description:
RecombinanthumanMARK3,fulllength,withN-terminalGST-tag,expressedinSf9insectcellsviaabaculovirusexpressionsystem.
Synonym(s):
KP78,CTAK1,PAR1A
Purity:
≥75%
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Göransson,O.etal:RegulationofthepolaritykinasesPAR-1/MARKby14-3-3interactionandPhosphorylation.J.CellSci.2006;119(19):4059-70.
2.Kato,T.etal:Isolationofanovelhumangene,MARKL1,homologoustoMARK3anditsinvolvementinhepatocellularcarcinogenesis.Neoplasia.2001;3(1):4-9.
2.Kato,T.etal:Isolationofanovelhumangene,MARKL1,homologoustoMARK3anditsinvolvementinhepatocellularcarcinogenesis.Neoplasia.2001;3(1):4-9.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
