Bpsbioscience/小鼠IDO1抑制剂筛选分析试剂盒/72041/96反应
商品编号：
72041
品牌：
bpsbioscience
市场价：
¥14900.00
美元价：
8940.00
产品分类：
其它检测试剂盒
公司分类：
Other_kits
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Background:
L-tryptophan(L-Trp)isanessentialaminoacidnecessaryforproteinsynthesisinmammaliancellsandtheL-Trptokynurenine(Kyn)pathwayisfirmlyestablishedasakeyregulatorofinnateandadaptiveimmunity.CatabolismofL-TrptoKynmaintainsanimmunosuppressivemicroenvironmentbystarvingimmunecellsofL-TrpandreleasingdegradationproductsofL-Trpthathaveimmunosuppressivefunctions.Indoleamine2,3-dioxygenases(IDO1&IDO2),twooftheratelimitingenzymesinthispathway,areupregulatedinmanytumors,providingcancercellswithanavenueforimmuneevasion.
Description:
TheMouseIDO1InhibitorScreeningAssayKitisdesignedtomeasureinhibitionofthemurineIDO1enzyme.Thiskitissimpletouse.InhibitorandenzymeareaddedtoasamplecontainingL-Trpsubstrate.Afteraroomtemperatureincubation,activityisdeterminedbymeasuringtheabsorptionofreactionproductatl=320-325nm.
Synonym(s):
Indoleamine2,3-dioxygenase1,IDO,IDO1
SuppliedAs:
Thekitcomesinaconvenientformat,withenoughreactionsolutionandenzymetoperformatotalof100reactions.
Contraindications:
DMSO>0.5%,strongacidsorbases,ionicdetergents,highsalt
Format:
COMPONENTS:
Instructionsforuse:
Seeassaykitdatasheetfordetailedprotocol
Storage/StABIlity:
Stableatleast6monthsfromdateofreceipt,whenstoredasdirected.Kitcomponentsrequiredifferentstorageconditions.Besuretostoreeachcomponentatthepropertemperatureuponarrival.
Application(s):
UsefulforthestudyofmouseIDO1enzymology,screeninginhibitorsandselectivityprofiling.
Reference(s):
1.Koblish,H.K.,etal.,MolCancerTher,2010;9(2):489-98
2.Liu,X.,etal.,Blood.2010;115(17):3520-3530.
3.Seegers,N.,etal.JBiomolScreen.2014;19(9):1266-74.
Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
Immunotherapy
ProductType:
AssayKit
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
