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当前位置: 首页 > 产品中心 > Routine_cell_strain > Bpsbioscience/LIGHT-CHO Recombinant Cell Line/79262/2 Vials
商品详细Bpsbioscience/LIGHT-CHO Recombinant Cell Line/79262/2 Vials
Bpsbioscience/LIGHT-CHO Recombinant Cell Line/79262/2 Vials
Bpsbioscience/LIGHT-CHO Recombinant Cell Line/79262/2 Vials
商品编号: 79262
品牌: bpsbioscience
市场价: ¥120000.00
美元价: 72000.00
产地: 美国(厂家直采)
公司:
产品分类: 常规细胞株
公司分类: Routine_cell_strain
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Background:
LIGHT(TNFSF14)isakeycomponentofthecommunicationsystemthatcontrolstheresponsesofT-Cells.LIGHTactivatestwocellsurfacereceptors,theHerpesvirusEntryMediator(HVEM)andtheLymphotoxin-betaReceptor(LTβR).TheLIGHT-HVEMaxisisanimportantcostimulatorypathwayforTcells,ithasbeenshowntoactivateNF-κB;LIGHT/HVEMpairareco-stimulatoryimmunecheckpointmoleculesforcancerimmunotherapy,LIGHTexpressingcellshavebeenshowntobemorepotentthanthesolubleLIGHTforactivatingHVEMexpressedonTcellsurface.
Description:
RecombinantstableclonalCHOcelllineconstitutivelyexpressingfulllengthhumanLIGHTprotein,alsoknownasTNFSF14,(Genbank#NM_003807).Surfaceexpressionisconfirmedbyflowcytometry.
Synonym(s):
TNFSF14
SuppliedAs:
Eachvialcontains~2x10^6cellsin1mlof10%DMSOinFBS.
HostCellline:
CHOK1,ChineseHamsterOvary
MycoplasmaTesting:
ThiscelllinehasbeenscreenedusingtheMycoAlert™MycoplasmaDetectionKit(Lonza,#LT07-118)toconfirmtheabsenceofMycoplasmacontamination.MycoAlertAssayControlSet(Lonza,#LT07-518)wasusedasapositivecontrol.
Instructionsforuse:
Seedatasheetfordetailedculturingandassayprotocol.
Storage/StABIlity:
Storeinliquidnitrogenimmediatelyuponreceipt.
Application(s):
ThiscelllineisusefulforLIGHTbindingassays,flowcytometry,orforscreeningforLIGHTantibodies.Alsousefulforimmunecheckpointco-stimulatoryassaywhenco-culturedwithHVEM/NF-κB-luciferase/Jurkatreportercellline(BPSBioscience).
Reference(s):

1.Chen,et.al.(2013)MolecularmechanismsofTcellco-stimulationandco-inhibition.NatRevImmunol.2013April;13(4):227–242.

2.Steinberg,et.al.(2014)TheSignalingNetworksoftheHerpesvirusEntryMediator(TNFRSF14)inImmuneRegulation.ImmunolRev.2011November;244(1):169–187.

3.Rio,et.al.(2014)TherapeuticblockadeofLIGHTinteractionwithHVEMandLTβRattenuatesinvivocytotoxicallogeneicresponses.Transplantation.2014December15;98(11):1165–1174.

Notes:
Contactusforpricing.

LicenseDisclosure:Purchaseofthiscelllinegrantsyouwitha10-yearlicensetousethiscelllineinyourimmediatelaboratory,forresearchuseonly.Thislicensedoesnotpermityoutoshare,distribute,sell,sublicense,orotherwisemakethecelllineavailableforusetootherlaboratories,departments,researchinstitutions,hospitals,universities,orbiotechcompanies.Thelicensedoesnotpermittheuseofthiscelllineinhumansorfortherapeuticordruguse.Thelicensedoesnotpermitmodificationofthecelllineinanyway.InappropriateuseordistributionofthiscelllinewillresultinrevocationofthelicenseandresultinanimmediateceaseofsalesanddistributionofBPSproductstoyourlaboratory.BPSdoesnotwarrantthesuitabilityofthecelllineforanyparticularuse,anddoesnotacceptanyliabilityinconnectionwiththehandlingoruseofthecellline.Modificationsofthiscellline,transfertoanotherfacility,orcommercialuseofthecellsmayrequireaseparatelicenseandadditionalfees;contactsales@bpSBIoscience.comfordetails.PublicationsusingthiscelllineshouldreferenceBPSBioscience,Inc.,SanDiego.

Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
Immunotherapy
ProductType:
CellLine
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。