Bpsbioscience/PRMT5/MEP50, Biotin-Labeled/52102/10 µg
商品编号：
52102
品牌：
bpsbioscience
市场价：
¥9800.00
美元价：
5880.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species: Human
Host Species: HEK293
MW: 73 kDa (PRMT5), 38 kDa (MEP50)
Genbank #: NM_006109 (PRMT5), NM_024102 (MEP50)
Tag(s): N-terminal FLAG-Avi-tag (PRMT5), N-terminal His-tag (MEP50)
a.a: 2–end (both)
Background:
Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overexpression is observed in breast cancer
Description:
PRMT5/MEP50 complex of human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-637(end), with N-terminal FLAG-Avi tag, MW=73 kDa, and human MEP50 (GenBank Accession No. NM_024102) with N-terminal His-Tag, amino-acids 2-342(end), MW=38 kDa, coexpressed in HEK293 cells and enzymatically biotin-labeled using Avi-tag™ technology.
Synonym(s):
PRMT5, HRMT1L5, IBP72, JBP1, SKB1, PRMT Protein, MEP50
Formulation:
40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 µg/mL FLAG peptide, 20% glycerol and 3 mM DTT.
Format:
Aqueous buffer solution
Storage / Stability:
At least 6 months at –80°C. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
Reference(s):
1. Zhao Q. et al., J. Nat. Struct. Mol. Biol. 16 (3), 304-311 (2009).
2. Wang L et al., Mol. Cell. Biol. 28 (20), 6262-6277 (2008).
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Methyltransferase
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
