4000-520-616
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4000-520-616
当前位置: 首页 > 产品中心 > cytokine > Bpsbioscience/LRRK2 (D1994A), GST-Tag/40831/10 µg
商品详细Bpsbioscience/LRRK2 (D1994A), GST-Tag/40831/10 µg
Bpsbioscience/LRRK2 (D1994A), GST-Tag/40831/10 µg
Bpsbioscience/LRRK2 (D1994A), GST-Tag/40831/10 µg
商品编号: 40831
品牌: bpsbioscience
市场价: ¥8400.00
美元价: 5040.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞因子
公司分类: cytokine
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:210kDa
Genbank#:NM_198578
Tag(s):N-terminalGSTtag
a.a:968-end
Background:
LRRK2orleucine-richrepeatkinaseisaproteinwithanankryinrepeatregion,aleucine-richrepeat(LRR)domain,akinasedomain,aDFG-likemotif,aRASdomain,aGTPasedomain,aMLK-likedomain,andaWD40domain.MutationsinLRRK2arethemostfrequentknowncauseofautosomaldominantandidiopathicParkinson"sdiseasewithprevalentmutationsbeingfoundwithintheGTPaseandkinasedomains(1).LRRK2cooperateswithMETtopromoteefficienttumorcellgrowthandsurvivalinvariouscancers.Down-regulationofLRRK2inculturedtumorcellscompromisesMETactivationandselectivelyreducesdownstreamMETsignalingtomTORandSTAT3(2).
Description:
HumanLRRK2proteinwithaD1994Amutation,alsoknownasPARK8,RIPK7,andROCO2,GenBankAccessionNo.NM_198578,aminoacids968-end,withanN-terminalGST-tag,expressedinanSF9cellexpressionsystem.MW=210kDa.
Synonym(s):
PARK8;RIPK7;ROCO2;AURA17;DARDARIN
SpecificActivity:
≥2.0pmol/min/µg
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,10mMglutathione,0.1mMEDTA,0.25mMDTT,0.1mMPMSF,25%glycerol.
Storage/StABIlity:
Storeproductat–70°C.Foroptimalstorage,aliquottargetintosmallerquantitiesaftercentrifugationandstoreatrecommendedtemperature.Formostfavorableperformance,avoidrepeatedhandlingandmultiplefreeze/thawcycles.
Application(s):
KinaseAssay
Reference(s):
1.YaoC.,etal.,NeurobiolDis.2010Oct;40(1):73-81.

2.LooyengaB.,ProcNatlAcadSciUSA.2011Jan25;108(4):1439-44

ScientificCategory:
Kinase
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。