Bpsbioscience/SMI-4a/27774-1/10 mg
商品编号：
27774-1
品牌：
bpsbioscience
市场价：
¥3300.00
美元价：
1980.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:273.2Da
CASRegistry#:438190-29-5
Formula:C11H6F3NO2S
Target:Pim1
Background:
Theserine/threoninePimkinaseshavebeensuggestedtopromotetheactivityoftherapamycin-sensitivemammaliantargetofrapamycin(mTORC1),whichregulatescellgrowthandsurvival.Pimkinasesareoverexpressedinsolidcancersandhematologicmalignancies,andassuchhavebecometargetsofsmallmoleculeinhibitorstopreventtheprogressionofvariouscancers.SIM-4aisaPimkinaseinhibitorthatblocksmTORC1activityviaactivationofAMPK.1SMI-4ahasbeenfoundtoinhibitprostatecancercellgrowthandinduceG1phasecell-cyclearrestinprecursorT-celllymphoblasticleukemia/lymphomacelllines.
Description:
SMI-4aisapotentinhibitorofPim1withIC50=17-21nM.Itdoesnotsignificantlyinhibitotherserine/threonine-ortyrosine-kinases.ItinducesG1phasecellcyclearrestandinducesapoptosisthroughthemitocondrialpathway.Itdownregulatesc-mycandinducesp27Kip1expression.InhibitsPRAS40phosphorylationandmTORactivity,aswellasthemammaliantargetofrapamycinC1(mTORC1)pathway.SMI-4aisapotentialanti-cancercompoundthatblocksprostatecancergrowth.
Synonym(s):
5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
BIOLOGicalActivity:
SMI-4aisaselectiveATP-competitivePim-1kinaseinhibitorwithanIC50of21nMforPim-1comparedtoanIC50of100nMforPim-2andwithlittleornoactivityagainstapanelof50otherkinasestested.SIM-4akillsawiderangeofbothmyeloidandlymphoidcelllines(withIC50valuesrangingfrom0.8to40µM).
Solubility:
SolubleinDMSO
Format:
whitetobeigepowder
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Y.W.Lin,etal.;Blood115,824(2010).
2.F.Zhang,etal.;CancerBiol.Ther.8,846(2009).
3.Z.Xia,etal.;J.Med.Chem.52,74(2009).
2.F.Zhang,etal.;CancerBiol.Ther.8,846(2009).
3.Z.Xia,etal.;J.Med.Chem.52,74(2009).
ScientificCategory:
Pim
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
