Bpsbioscience/Sepantronium Bromide/27066/10 mg
商品编号：
27066
品牌：
bpsbioscience
市场价：
¥2300.00
美元价：
1380.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 443.3 Da
Genbank #: 781661-94-7
Formula: C20H19BrN4O3
Description:
Sepantronium bromide, also known as YM155, is a novel small molecule inhibitor of expression of the apoptosis inhibiting protien, survivin, which itself is an inhibitor of apoptosis.
Synonym(s):
Sepantronium bromide, YM155
Purity:
>98% by HPLC
Biological Activity:
Sepantronium bromide exhibited an IC50 of 0.54 nM for the inhibition of survivin promoter activity. It inhibited the the growth of various human cancer cell lines in vitro with GI50 values in the low nM range. Sepantronium bromide blocked the growth of 119 human cancer cell lines, with the greatest inhibition in lines derived from non-Hodgkin's lymphoma, hormone-refractory prostate cancer, ovarian cancer, sarcoma, non-small-cell lung cancer, breast cancer, leukemia and melanoma ,with an average IC50 of 15 nM. Sepantronium bromide inhibited the growth of tumor cell lines regardless of their p53 status and demonstrated significant antitumor activity in 5 mice xenograft models. It also caused tumor regressions in vivo, possibly by its effects in reducing intratumoral survivin expression levels and increasing apoptosis.
Solubility:
Soluble in DMSO ≥85mg/ml, water ≥85mg/ml, ethanol ≥20mg/ml
Format:
A crystalline solid.
Storage / Stability:
Store at or below -20°C. Stable for at least 1 year when stored as directed. Anhydrous DMSO stock solutions are stable for at least 3 months.
Reference(s):
1. Nakahara, T., et al. Cancer Res. 67: 8014-8021 (2007).
2. Nakahara, T., et al. Cancer Sci. 102: 614-621 (2011).
2. Nakahara, T., et al. Cancer Sci. 102: 614-621 (2011).
Warning(s):
Protect from moisture. Avoid freeze/thaw cycles of solutions.
Scientific Category:
Protease
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
