Bpsbioscience/人类RANTES（CCL5）/90232-A/5µg
商品编号：
90232-A
品牌：
bpsbioscience
市场价：
¥2600.00
美元价：
1560.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species: Human
Host Species: E. coli
MW: 8 kDa
Genbank #: P13501
a.a: 24–91
Background:
RANTES belongs to the family of chemotactic cytokines known as Chemokines. RANTES is expressed by an early response gene. The synthesis of RANTES is induced by TNF-alpha and IL-1alpha. RANTES is chemotactic for T-cells, human eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. RANTES also activates eosinophils to release eosinophilic cationic protein. It changes the density of eosinophils and makes them hypodense, which is thought to represent a state of generalized cell activation and is associated most often with diseases such as asthma and allergic rhinitis. RANTES also is a potent activator of oxidative metabolism specific for eosinophils. RANTES increases the adherence of monocytes to endothelial cells. It selectively supports the migration of monocytes and T-lymphocytes expressing the cell surface markers CD4 and UCHL1. These cells are thought to be pre-stimulated T-helper cells with memory T-cell functions. RANTES activates human basophils from some select basophil donors and causes the release of histamines.
UniProt
P13501
Synonym(s):
CCL5, RANTES, Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted, Eosinophil Chemotactic Cytokine, Small-Inducible Cytokine A5, T-Cell Specific Protein P28
Purity:
≥98% by SDS-PAGE and HPLC
Endotoxin Level:
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity:
Determined by its ability to chemoattract human blood monocytes using a concentration range of 1.0-10.0 ng/ml.
Formulation:
Lyophilized from a 0.2 µm filtered PBS solution.
Format:
lyophilized protein
Reconstitution:
Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.
Storage / Stability:
The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.
Reference(s):
1. Lv, D., et al. Cell Mol Immunol. 2013 Jul,10(4):303-10.
2. Suffee N, et al.
2. Biochem Soc Trans. 2011 Dec,39(6):1649-53.
3. Katsounas A, et al. Int Rev Immunol. 2011 Oct-Dec,30(5-6):366-78.
2. Suffee N, et al.
2. Biochem Soc Trans. 2011 Dec,39(6):1649-53.
3. Katsounas A, et al. Int Rev Immunol. 2011 Oct-Dec,30(5-6):366-78.
Warning(s):
Avoid freeze/thaw cycles
Amino Acid Sequence:
SPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS
Scientific Category:
Cytokine/Growth Factors
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
