Bpsbioscience/Vardenafil HCl Trihydrate/27776-2/10 mg
商品编号：
27776-2
品牌：
bpsbioscience
市场价：
¥3200.00
美元价：
1920.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 579.1 Da
CAS Registry #: 224785-90-4
Formula: C23H32N6O4S • HCl • 3 >H2O
Target: PDE5
Background:
Vardenafil is frequently used in the treatment erectile dysfunction, and is the active ingredient in Levitra. It has been reported to significantly enhance the SNP-induced, ACh-induced and transmural electrical stimulation-induced relaxation of human trabecular smooth muscle. Vardenafil has been revealed to increase the amount of cGMP in human corpus cavernosum.
Description:
Vardenafil is a potent and selective inhibitor of phosphodiesterase type5 (PDE5) with the IC50 value of 0.7 nM in enzymatic assay in vitro.
Synonym(s):
2-[2-Ethoxy-5-(4-ethyl-piperazine-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one monohydrochloride trihydrate
Biological Activity:
Vardenafil has shown a greater selective inhibition towards PDE5 (IC50 = 0.7 nM) vs. PDEs from bovine, with the IC50 values of 180 nM, >10 µM, 2.5 µM, 4 µM and 11 nM for PDE1, PDE2, PDE3, PDE4 and PDE6, respectively. It is shows selectivity for PDE5 vs. over 300-fold relative to PDE11 and over 1000-fold relative to PDEs 8, 9, and 10.
Solubility:
Soluble in ethanol or 0.1M HCl. Only slightly soluble in water.
Format:
nearly colourless solid
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
Saenz de Tejada I., et al. Int J Impot Res. 2001 Oct;13(5):282-90.
Scientific Category:
PDE Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
