Bpsbioscience/Tadalafil/27657-3/500 mg
商品编号:
27657-3
品牌:
bpsbioscience
市场价:
¥11500.00
美元价:
6900.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
MW: 389.4 Da
CAS Registry #: 171596-29-5
Formula: C22H19N3O4
Target: PDE5
Background:
Tadalafil is a small-molecule inhibitor of phosphodiesterase 5 (PDE5), a predominant PDE in the pulmonary vasculature that hydrolyzes cyclic guanosine monophosphate (cGMP) and is involved in the pathobiology of pulmonary arterial hypertension (PAH). Although it is used for the treatment of erectile dysfunction through oral administration, tadalafil also improves the vasoconstrictive-predominate condition of PAH through elevating cGMP levels in pulmonary vessels resulted from PDE5 inhibition.
Description:
Tadalafil, also known as IC351 or Cialis, is a potent, reversible and competitive small-molecule inhibitor of PDE5
Synonym(s):
IC351; Cialis; (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione
Purity:
≥98% by HPLC
Biological Activity:
Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM. The inhibitory effect of tadalafil is PDE5 specific with the selectivity of 10000 fold greater than that of PDE1, PDE4, PDE7, PDE8, PDE9 and PDE10 and 780 fold greater than PDE6.
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Sawamura, F., et al. J Pharmacol Sci 111, 235-243 (2009)
2. Porst, H. Int. J. Impotence Res. (2002) 14, Suppl 1, S57-S64.
3. Forgue, S.T., et al. Br J Clin Pharmacol (2005); 61(3): 280-288.
2. Porst, H. Int. J. Impotence Res. (2002) 14, Suppl 1, S57-S64.
3. Forgue, S.T., et al. Br J Clin Pharmacol (2005); 61(3): 280-288.
Scientific Category:
PDE Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。