Bpsbioscience/他达拉非/27657-1/50毫克
商品编号：
27657-1
品牌：
bpsbioscience
市场价：
¥2800.00
美元价：
1680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:389.4Da
CASRegistry#:171596-29-5
Formula:C22H19N3O4
Target:PDE5
Background:
Tadalafilisasmall-moleculeinhibitorofphosphodiesterase5(PDE5),apredominantPDEinthepulmonaryvasculaturethathydrolyzescyclicguanosinemonophosphate(cGMP)andisinvolvedinthepathoBIOLOGyofpulmonaryarterialhypertension(PAH).AlthoughitisusedforthetreatmentoferectiledysfunctionthroughoraladmiNISTration,tadalafilalsoimprovesthevasoconstrictive-predominateconditionofPAHthroughelevatingcGMPlevelsinpulmonaryvesselsresultedfromPDE5inhibition.
Description:
Tadalafil,alsoknownasIC351orCialis,isapotent,reversIBLeandcompetitivesmall-moleculeinhibitorofPDE5
Synonym(s):
IC351;Cialis;(6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1",2":1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione
Purity:
≥98%byHPLC
BiologicalActivity:
TadalafilisaPDE-5inhibitorwithIC50of1.8nM.TheinhibitoryeffectoftadalafilisPDE5specificwiththeselectivityof10000foldgreaterthanthatofPDE1,PDE4,PDE7,PDE8,PDE9andPDE10and780foldgreaterthanPDE6.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Sawamura,F.,etal.JPharmacolSci111,235-243(2009)
2.Porst,H.Int.J.ImpotenceRes.(2002)14,Suppl1,S57-S64.
3.Forgue,S.T.,etal.BrJClinPharmacol(2005);61(3):280-288.
2.Porst,H.Int.J.ImpotenceRes.(2002)14,Suppl1,S57-S64.
3.Forgue,S.T.,etal.BrJClinPharmacol(2005);61(3):280-288.
ScientificCategory:
PDEInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
