Bpsbioscience/S- (+)-Rolipram/27648-1/10 mg
商品编号：
27648-1
品牌：
bpsbioscience
市场价：
¥3000.00
美元价：
1800.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 275.3 Da
CAS Registry #: 85416-73-5
Formula: C16H21NO3
Target: PDE4B
Background:
Rolipram is a racemic drug that increases brain cAMP availability by inhibiting phosphodiesterase. The S-(+)-Rolipram enantiomer is 2-10x less potent than the R-(-)-Rolipram compound. PDE4B is involved in dopamine-associated and stress-related behaviours, and is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram.
Description:
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.
Synonym(s):
(4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Schneider et al (1986). Eur.J.Pharmacol. 127 105.
2. Owens et al (1997). Biochem.J. 326 53.
3. Ohsawa et al (1998). Jpn.J.Pharmacol. 77 147.
2. Owens et al (1997). Biochem.J. 326 53.
3. Ohsawa et al (1998). Jpn.J.Pharmacol. 77 147.
Scientific Category:
PDE Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
