Bpsbioscience/HGK (MAP4K4 ), GST-tag/40109/10 µg
商品编号：
40109
品牌：
bpsbioscience
市场价：
¥7800.00
美元价：
4680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:64kDa
Genbank#:NP_004825
Tag(s):N-terminalGST-tag
a.a:1–328
Background:
HGKisthemitogen-activatedproteinkinasekinasekinasekinase4(MAP4K4)andamemberoftheserine/threonineproteinkinasefamily.HGKhasbeenshowntospecificallyactivateMAPK8/JNK(1).TheactivationofMAPK8byHGKcanbeinhibitedbydominant-negativemutantsofMAP3K7/TAK1,MAP2K4/MKK4,andMAP2K7/MKK7,whichsuggestthatthiskinasefunctionsthroughtheMAP3K7-MAP2K4-MAP2K7kinasecascadeandmediatesTNF-αsignaling.HGK-dependentsignalinginhibitsPPARγ-responsivegeneexpression,ADIpogenesis,andinsulin-stimulatedglucosetransport(2).
Description:
RecombinanthumanHGK(a.a.1-328),withN-terminalGST-tag,expressedinSf9insectcellsviaabaculovirusexpressionsystem.
Synonym(s):
MAP4K4,NIK,FLH21957,FLJ10410,FLJ20373,FLJ90111,KIAA0687
Purity:
≥90%
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,10mMglutathione,0.1mMEDTA,0.25mMDTT,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Yao,Z.et.al:AnovelhumanSTE20-relatedproteinkinase,HGK,thatspecificallyactivatesthec-junN-terminalkinasesignalingpathway.J.Biol.Chem.274:2118-2125,1999.
2.Tang,X.et.al:AnRNAinterference-basedscreenidentifiesMAP4K4/NIKasanegativeregulatorofPPAR-gamma,adipogenesis,andinsulin-responsivehexosetransport.Proc.Nat.Acad.Sci.103:2087-2092,2006.
2.Tang,X.et.al:AnRNAinterference-basedscreenidentifiesMAP4K4/NIKasanegativeregulatorofPPAR-gamma,adipogenesis,andinsulin-responsivehexosetransport.Proc.Nat.Acad.Sci.103:2087-2092,2006.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
