Bpsbioscience/EIF2AK3, GST-tag/40059/10 µg
商品编号：
40059
品牌：
bpsbioscience
市场价：
¥7800.00
美元价：
4680.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:115kDa
Genbank#:NM_004836
Tag(s):N-terminalGST-tag
a.a:563–1115
Background:
EIF2AK3phosphorylatesthealphasubunitofeukaryotictranslation-initiationfactor2(EIF2)leADIngtoitsinactivationandarapidreductionoftranslationalinitiationandrepressionofglobalproteinsynthesis.EIF2AK3isatypeImembraneproteinlocatedintheendoplasmicreticulum(ER),whereitisinducedbyERstresscausedbymalfoldedproteins(1).EIF2AK3playsamajorroleintheABIlityofcellstoadapttoERstressandisalsoinvolvedinanintegratedadaptiveresponsetohypoxicstressinHeLacells(2).EIF2AK3functionsinironhomeostasisandmayplayaroleinhemolyticandinflammatoryanemia.
Description:
RecombinanthumanEIF2AK3(a.a.563-1115),withN-terminalGST-tag,expressedinE.colicells
Synonym(s):
PERK,PEK,WRS,HRI,DKFZp781H1925,double-strandedRNA-activatedproteinkinase
Purity:
≥90%
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,10mMglutathione,0.1mMEDTA,0.25mMDTT,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/Stability:
>6monthsat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Harding,H.P.et.al:EIF2AK3isessentialfortranslationalregulationandcellsurvivalduringtheunfoldedproteinresponse.Molec.Cell5:897-904,2000.
2.Blais,J.D.et.al:Activatingtranscriptionfactor4istranslationallyregulatedbyhypoxicstress.Molec.Cell.Biol.24:7469-7482,2004.
2.Blais,J.D.et.al:Activatingtranscriptionfactor4istranslationallyregulatedbyhypoxicstress.Molec.Cell.Biol.24:7469-7482,2004.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
