Bpsbioscience/NLG919/27337-2/50毫克
商品编号：
27337-2
品牌：
bpsbioscience
市场价：
¥11800.00
美元价：
7080.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:282.4Da
CASRegistry#:1402836-58-1
Formula:C18H22N2O
Description:
NLG919isanorallyavailablepotentinhibitoroftheindoleamine-2,3-dioxygenase(IDO)pathway,acrucialpathwayinvolvedinallergicinflammationthatmediatesimmunosuppressiveeffectsthroughmetabolizationoftryptophantokynurenine.NLG919affectsdifferentiationandproliferationofTcellsbyinducingdownstreamsignalingviaGCN2,mTORandAHR,withvaluesofKi=7nMandEC50=75nM.NLG919isbeinginvestigatedforthetreatmentofimmunosuppressionassociatedwithcancer.
Synonym(s):
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol,IDOinhibitor
Purity:
≥98%
BIOLOGicalActivity:
NLG919potentlyblocksIDO-inducedTcellsuppressionandrestoredTcellresponseswithareportedED50of80nMinvitro.NLG919reducedtheconcentrationofplasmaandtissuekynurenineby~50%afterasingledoseinmice.NLG919enhancedtheantitumorresponsesofnaïve,restingpmel-1T-cellstovaccinationwithcognatehgp100peptideplusCpG-1826inIFAinmicebearingB16F10tumors.
Solubility:
SolubleinDMSOat15mg/ml.
Format:
Whitepowder
Storage/StABIlity:
Storeassuppliedatorbelow-20°Cforupto3years.StableinDMSOat-80°Cforupto6months.
Reference(s):
1.Driessens,G.,etal.,J.Immunother.Cancer.2014;2(Suppl3):195.
2.Nayak,A.,etal.J.Immunother.Cancer.2014;2(Suppl3):250.
ScientificCategory:
Immunotherapy
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
