Bpsbioscience/NLG919/27337-1/10 mg
商品编号：
27337-1
品牌：
bpsbioscience
市场价：
¥3600.00
美元价：
2160.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 282.4 Da
CAS Registry #: 1402836-58-1
Formula: C18H22N2O
Description:
NLG919 is an orally available potent inhibitor of the indoleamine-2,3-
dioxygenase (IDO1) pathway, a crucial pathway involved in allergic inflammation that mediates
immunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919
affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2,
mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated for
the treatment of immunosuppression associated with cancer.
Synonym(s):
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol, IDO inhibitor
Purity:
≥98%
Biological Activity:
NLG919 potently blocks IDO-induced T cell suppression and restored T
cell responses with a reported ED50 of 80 nM in vitro. NLG919 reduced the concentration of
plasma and tissue kynurenine by ~50% after a single dose in mice. NLG919 enhanced the
antitumor responses of naïve, resting pmel-1 T-cells to vaccination with cognate hgp100 peptide
plus CpG-1826 in IFA in mice bearing B16F10 tumors.
Solubility:
Soluble in DMSO at 15 mg/ml.
Format:
White powder
Storage / Stability:
Store as supplied at or below -20°C for up to 3 years. Stable in DMSO at
-80°C for up to 6 months.
Reference(s):
1. Driessens, G., et al., J. Immunother. Cancer. 2014; 2(Suppl 3):195.
2. Nayak, A., et al. J. Immunother. Cancer. 2014; 2(Suppl 3): 250.
Scientific Category:
Immunotherapy
Product Type:
Inhibitors/Activators
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
