Bpsbioscience/Mocetinostat（MGCD0103）/27109/5 mg
商品编号：
27109
品牌：
bpsbioscience
市场价：
¥7600.00
美元价：
4560.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 396.4 Da
CAS Registry #: 726169-73-9
Formula: C23H20N6O
Description:
Mocetinostat (MGCD0103) is an HDAC inhibitor. It was shown to induce hyperacetylation of histones resulting in cancer cell selective apoptosis, and cause cell cycle blockade in various human cancer cell lines in a dose-dependent manner. Mocetinostat inhibites growth of human tumor xenografts in nude mice in a dose-dependent manner and its antitumor activity correlates with induction of histone acetylation in tumors.
Synonym(s):
MGCD0103
Purity:
≥99% by HPLC
Biological Activity:
Mocetinostat (MGCD0103) inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 0.15 µM, 0.29 µM and 1.66 µM, respectively.
Solubility:
Solubility in DMSO is 13 mg/ml, and in water and ethanol is < 1 mg/ml. DMSO stock solutions are stable up to one week at 4ºC or up to a month at -70ºC. Do not store aqueous solutions for more than one day.
Format:
A crystalline solid
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 2 years from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Foumel, M., et al., Mol Cancer Ther. 2008;7:759-768.
2. Duque-Afonso, J., et al. Oncogene 2011. July;30:3062-72.
3. Munkacsi, A.B., et al. J. Biol. Chem. 2011. July;286:23842-51.
4. Xu, X., et al. PLoS ONE. February 2011. 6:e17138.
2. Duque-Afonso, J., et al. Oncogene 2011. July;30:3062-72.
3. Munkacsi, A.B., et al. J. Biol. Chem. 2011. July;286:23842-51.
4. Xu, X., et al. PLoS ONE. February 2011. 6:e17138.
Scientific Category:
HDAC
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
