4000-520-616
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当前位置: 首页 > 产品中心 > cytokine > Bpsbioscience/CD73 His-tag (Human) HiP™/71184/50 µg
商品详细Bpsbioscience/CD73 His-tag (Human) HiP™/71184/50 µg
Bpsbioscience/CD73 His-tag (Human) HiP™/71184/50 µg
Bpsbioscience/CD73 His-tag (Human) HiP™/71184/50 µg
商品编号: 71184
品牌: bpsbioscience
市场价: ¥6000.00
美元价: 3600.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞因子
公司分类: cytokine
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Species:Human
HostSpecies:HEK293
MW:58.6kDa
Genbank#:NM_002526
Tag(s):C-terminalHis-tag
a.a:27-547
Background:

CD39contributestoimmuneregulationthroughthehydrolysisofATPtoAMPintheratelimitingstepofextracellularadenosineproduction.CD39isexpressedonthesurfaceofmultiplecellsoftheimmunesystemincludingT-cells,Naturalkillercells,B-cells,dendriticcellsandmacrophages.Inaddition,highlevelsofCD39expressionhavebeenassociatedwiththetumormicroenvironment(TME).ResearchaimedatreducingimmunosuppressionbyCD39activityhasresultedinthestudyofasmallmoleculeinhibitor,POM1,andmultipleanti-CD39antibodiesselectedforblockingenzymaticactivity ordecreasingCD39expression. 

Description:

HumanCD73protein,alsoknownas5"-nucleotidaseandEcto-5"-nucleotidase,GenBankAccessionNo.NM_002526,a.a.27-547withC-terminalHis-tag,expressedinaHEK293cellexpressionsystem.MW=58.6kDa.ThisproteinrunsatahigherMWbySDS-PAGEduetoglycosylation.

UniProt
P21589
Synonym(s):
5"-nucleotidase,Ecto-5"-nucleotidase,CD73,CD73Protein
SpecificActivity:
≥ 20nmol/min/μg
AssayConditions:
Assaywasdonein50µLassaybuffercontaining25mMTris,pH7.4,5mMMgCl2and100µMAMPfor12minat37ºC.InorganicphosphateproducedwasmeasuredusingBiomolGreenreagent.
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,and20%glycerol
Format:
Aqueousbuffersolution
Storage/StABIlity:
Atleast6monthsat–80°C.
Application(s):
Usefulforstudyingenzymekinetics,substratespecificity,andscreeninginhibitors.
Reference(s):
1.Deaglio,S.etal.,J.Exp.Med.2007;204(6):1257-1265.
2.Thompson,L.F.,etal.,J.Exp.Med.2004;200(11):1395-1405.
Notes:

HiP™indicatesahighpurityproteinwith≥90%purityasmeasuredbygelfiltration.

Warning(s):
Avoidfreeze/thawcycles.Storingdilutedproteinisnotrecommended,ifnecessary,usecarrierprotein(BSA0.1–0.5%).
ScientificCategory:
Immunotherapy
ProductType:
Recombinantprotein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。