Bpsbioscience/Tubastatin A盐酸盐/27108/10 mg
商品编号：
27108
品牌：
bpsbioscience
市场价：
¥6200.00
美元价：
3720.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 371.9 Da
CAS Registry #: 1310693-92-5
Formula: C20H21N3O2•HCl
Description:
Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces a-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 µM.
Purity:
≥98% by HPLC.
Biological Activity:
Inhibits HDAC6 with IC50 = 15 nM and HDAC1 with IC50 = 16.4 µM.
Solubility:
Solubility in DMSO is 8 mg/ml, and in water and ethanol is < 1 mg/ml.
Format:
White to off-white crystalline solid; granular or powder.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Butler, K.V., et al. J Am Chem Soc. 2010; 132(31): 10842-6.
Application References:
1. Histone deacetylase 6 (HDAC6) is an essential factor for oocyte maturation and asymmetric division in mice (2017)
Scientific Category:
HDAC
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
