Bpsbioscience/SRT1720/27655-2/10毫克
商品编号：
27655-2
品牌：
bpsbioscience
市场价：
¥5200.00
美元价：
3120.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:506.0Da
CASRegistry#:1001645-58-4
Formula:C25H23N7OS•HCl
Target:SIRT1
Description:
SRT1720isasmall-moleculecompoundwhichhastheABIlityofactivatingthesirtuinsubtypeSIRT1invitro.SRT1720hassimilaractivityinthebodytotheknownSIRT1activatorresveratrol,butis1000xmorepotent.ItaffectsmitochondrialrespirationinaSirt1-andPGC-1α-dependentmanner.SRT1720hasbeendemonstratedtoenhanceinsulinsensitivityandimprovemeasuresofmitochondrialcapacityandoxidativemetabolism.Treatmentofmultiplemyeloma(MM)cellswithSRT1720inhibitsgrowthandinducedapoptosisinMMcellsresistanttoconventionalandbortezomibtherapieswithoutsignificantlyaffectingtheviabilityofnormalcells.SRT1720isabletoenhancethecytotoxicactivityofbortezomibordexamethasone.Anti-MMactivityofSRT1720isrelatedto:1)activationofcaspase-8,caspase-9,caspase-3,poly(ADP)ribosepolymerase;2)increaseinreactiveoxygenspecies;3)inductionofphosphorylatedataxiatelangiectasiamutated/checkpointkinase2signaling;4)decreaseinvascularendothelialgrowthfactor-inducedmigrationofMMcellsandassociatedangiogenesis;and5)inhibitionofnuclearfactor-κB.
Synonym(s):
N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;hydrochloride
Purity:
≥98%byHPLC
BIOLOGicalActivity:
TheEC50forSIRT1is0.16µM
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
ScientificCategory:
DeacetylaseActivator
ProductType:
Activator/Inducer
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
