Bpsbioscience/人单核细胞趋化蛋白-1/90211-A/5µg
商品编号：
90211-A
品牌：
bpsbioscience
市场价：
¥2600.00
美元价：
1560.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:9kDa
Genbank#:P13500
a.a:24–99
Background:
MCP-1(MonocyteChemotacticProtein-1)belongstothefamilyofchemotacticcytokines.MCP-1isexpressedbymonocytes,vascularendothelialcells,smoothmusclecells,glomerularmesangialcell,osteoblasticcells.MCP-1hasbeenshowntoexhibitBIOLOGicalactivitiesotherthanChemotaxis.ItcaninducetheproliferationandactivationofkillercellsknownasCHAK.ElevatedlevelsofMCP-1areobservedinatheroscleroticplaquesthatarerichinmacrophages.Thefactoractivatesthetumoricidalactivityofmonocytesandmacrophagesinvivo.Itregulatestheexpressionofcellsurfaceantigens(CD11c,CD11b)andtheexpressionofcytokines(IL-1,IL-6).MCP-1isapotentactivatorofhumanbasophils,inducingdegranulationandthereleaseofhistamines.InbasophilsactivatedbyIL-3,IL-5orGM-CSF,MCP-1enhancesthesynthesisofleukotrieneC4.
Description:
HumanMCP-1,generatedbytheproteolyticremovalofthesignalpeptideandpropeptideandhasacalculatedmolecularmassofapproximately9kDa.RecombinantMCP-1isadisulfide-linkedmonomericproteinconsistingof77aminoacidresiduesandmigratesasanapproximately9kDaproteinundernon-reducingconditionsandreducingconditionsinSDS-PAGE.OptimizedDNAsequenceencodinghumanMCP-1(CCL2)maturechainwasexpressedinE.coli.
UniProt
P13500
Synonym(s):
MCP-1,CCL2,MCAF,MonocyteChemotacticProtein,HC11,Chemokine(C-CMotif)Ligand2,MCP1
Purity:
≥98%bySDS-PAGEandHPLC
EndotoxinLevel:
<0.1ng/µg(1EU/µg),usingtheLALgelclotmethod.
BiologicalActivity:
DeterminedbyitsABIlitytochemoattracthumanmonocytesusingaconcentrationrangeof2.0-40.0ng/ml.
Formulation:
Lyophilizedfroma0.2µmfilteredPBSsolution,pH7.4.
Format:
lyophilizedprotein
Reconstitution:
Reconstituteat0.1-1.0mg/mlindistilledwater.Thissolutioncanthenbedilutedintootherbuffers.Tomaximizeproductcollectionfromvialsurface,vortexbrieflyandthenspindowntorecollecttheliquid.
Storage/Stability:
Thelyophilizedproteinisstableforatleast2yearsfromdateofreceiptwhenstoredat-20°C.Uponreconstitution,storeinworkingaliquotsat+4°Cforuptoonemonth,orat-20°Cforuptosixmonths,inthepresenceofacarrierprotein.Avoidrepeatedfreeze/thawcycles.
Reference(s):
1..Biol.Chem.,Oct2009,284:27620-27628.
2.AmJPhysiolHeartCircPhysiol,Oct2009,297:H1208-H1216.
3.J.Immunol.,Sep2009,183:3463-3471.
2.AmJPhysiolHeartCircPhysiol,Oct2009,297:H1208-H1216.
3.J.Immunol.,Sep2009,183:3463-3471.
Warning(s):
Avoidfreeze/thawcycles
AminoAcidSequence:
QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
ScientificCategory:
Cytokine/GrowthFactors
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
