Bpsbioscience/人白细胞介素-6/90196-B/20µg
商品编号：
90196-B
品牌：
bpsbioscience
市场价：
¥4100.00
美元价：
2460.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:20kDa
Genbank#:P05231
a.a:30–212
Background:
IL-6isamemberofafamilyofcytokines,whichalsoincludesLIF,CNTF,OncostatinM,IL11,andCT-1.AllknownmembersoftheIL-6cytokinefamilyinducehepaticexpressionofacutephaseproteins.IL-6isproducedbymanydifferentcelltypes.Themainsourcesinvivoarestimulatedmonocytes,fibroblasts,andendothelialcells.Macrophages,T-cellsandB-lymphocytes,granulocytes,smoothmusclecells,eosinophils,chondrocytes,osteoblasts,mastcells,glialcells,andkeratinocytesalsoproduceIL-6afterstimulation.TheIL-6receptorisexpressedonT-cells,mitogen-activatedB-cells,peripheralmonocytesandsomemacrophage-andB-cellderivedtumorcelltypes.ItisnotexpressedinrestingB-cellsbutinrestingT-cells.TheIL-6receptor(CD126)isastronglyglycosylatedproteinof80kDaandalengthof449aminoacids.
Description:
RecombinanthumanIL-6isaglycosylateddisulfide-linkedhomodimericproteinconsistingof184aminoacidresidues,andmigratesasanapproximately20kDaproteinundernon-reducingandreducingconditionsinSDS-PAGE.OptimizedDNAsequenceencodingHumanInterleukin-6maturechainwasexpressedinE.coli.
UniProt
P05231
Synonym(s):
il-6,Interleukin6,CD126,IL6
Purity:
≥97%bySDS-PAGEandHPLC
EndotoxinLevel:
<0.1ng/µg(1EU/µg),usingtheLALgelclotmethod.
BIOLOGicalActivity:
TheED50wasdeterminedbythedose-dependentstimulationoftheproliferationofmurine7TD1cellstobelessthan0.1ng/ml,correspondingtospecificactivityof1x107IU/mg.
Formulation:
Lyophilizedfroma0.2µmfilteredPBSsolution,pH7.0.
Format:
lyophilizedprotein
Reconstitution:
Reconstituteat0.1-1.0mg/mlindistilledwater.Thissolutioncanthenbedilutedintootherbuffers.Tomaximizeproductcollectionfromvialsurface,vortexbrieflyandthenspindowntorecollecttheliquid.
Storage/StABIlity:
Thelyophilizedproteinisstableforatleast2yearsfromdateofreceiptwhenstoredat-20°C.Uponreconstitution,storeinworkingaliquotsat+4°Cforuptoonemonth,orat-20°Cforuptosixmonths,inthepresenceofacarrierprotein.Avoidrepeatedfreeze/thawcycles.
Reference(s):
1.Am.J.Respir.CellMol.Biol.,Oct2009,41:385-396.
2.AnnRheumDis,Oct2009,68:1580-1584.
3.Glycobiology,Oct2009,19:1082-1093.
2.AnnRheumDis,Oct2009,68:1580-1584.
3.Glycobiology,Oct2009,19:1082-1093.
Warning(s):
Avoidfreeze/thawcycles
AminoAcidSequence:
VPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
ScientificCategory:
Cytokine/GrowthFactors
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
