Bpsbioscience/Human Interleukin-31/90190-B/10 µg
商品编号：
90190-B
品牌：
bpsbioscience
市场价：
¥4100.00
美元价：
2460.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species: Human
Host Species: E. coli
MW: 18 kDa
Genbank #: Q6EBC2
a.a: 24–164
Background:
IL-31 is a recently discovered helical cytokine, belonging to the gp130/IL-6 cytokine family.The receptors for IL- 6 family are type I receptors, and they share a number of common structural motifs, such as the cytokine-binding domain with two pairs of conserved cysteine residues and a WSXWS sequence motif in the extracellular domain. IL-31 is expressed preferentially by activated Th2 CD4+ T cells, signaling through a heterodimeric receptor complex composed of IL-31RA and OSMR. Recent studies in both humans and mice have suggested a link between IL- 31/IL-31R expression and skin inflammation although the functional significance of endogenous IL-31/IL-31R interactions in influencing innate and adaptive immune responses remains unknown.
Description:
Recombinant Interleukin-31 is a disulfide-linked monomer protein consisting of 142 amino acid residues, and migrates as an approximately 18 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-31 mature chain was expressed in E. coli.
UniProt
Q6EBC2
Synonym(s):
IL-31, interleukin 31 , IL31
Purity:
≥95% by SDS-PAGE and HPLC
Endotoxin Level:
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity:
The ED50 was determined by the ability to induce STAT3 activation in U87MG cells, and was determined to be ≥ 7 ng/ml.
Formulation:
Lyophilized from a 0.2 µm filtered PBS solution, pH 7.5.
Format:
lyophilized protein
Reconstitution:
Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.
Storage / Stability:
The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.
Reference(s):
1. J. Immunol., May 2009, 182: 6088 - 6094.
2. Invest. Ophthalmol. Vis. Sci., Apr 2008, 49: 2531.
3. J. Exp. Med., Mar 2007, 204: 481 - 487.
2. Invest. Ophthalmol. Vis. Sci., Apr 2008, 49: 2531.
3. J. Exp. Med., Mar 2007, 204: 481 - 487.
Warning(s):
Avoid freeze/thaw cycles
Amino Acid Sequence:
SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
Scientific Category:
Cytokine/Growth Factors
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
