Bpsbioscience/PD-L1（CD274），Fc fusion（人类）髋关节与贸易/71104-2/100微克
商品编号：
71104-2
品牌：
bpsbioscience
市场价：
¥5900.00
美元价：
3540.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species: Human
Host Species: HEK293
MW: 52 kDa
Genbank #: NM_014143
Tag(s): C-terminal Fc fusion (Human IgG1)
a.a: 19–239
Background:
PD-L1 is involved in the costimulatory signal essential for T-cell proliferation and production of IL-10 and IFNgamma. Interaction with PD-1 inhibits T-cell proliferation and cytokine
production, and down-regulates the immune response. PD
Description:
Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein, also known as CD274 and B7 homolog 1 (B7- H1), GenBank Accession No. NM_014143, amino acids 19-239, fused at the C-terminus to the Fc portion of human IgG1, expressed in a HEK293 cell expression system. MW = 52 kDa.
UniProt
Q9NZQ7
Synonym(s):
Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
Assay Conditions:
PD-L1 binding to PD-1
was tested following protocol for BPS Cat.
#72005. Briefly, wells were coated with 10
ng of PD-L1 in PD-1 assay buffer. Varying
concentrations of biotinylated PD-1 was
added and wells were incubated at room
temp. for 2 hours before adding strep-HRP,
followed by chemiluminescent substrate.
Luminescence was read on a
chemiluminescent plate reader.
Formulation:
8 mM phosphate, pH 7.4,
110 mM NaCl, 2.2 mM KCl, and 20%
glycerol
Format:
Aqueous buffer solution
Storage / Stability:
At least 6 months at –80°C.
Application(s):
Useful for the study of protein-protein interaction and in vitro and in vivo protein function.
Reference(s):
1. Freeman, G.J., et al., J Exp Med. 2000 Oct 2;192(7):1027-34.
2. Dong, H., et al., Nat Med. 1999 Dec; 5(12):1365-9.
Application Reference(s):
Cutting Edge: PD-1 Regulates Imiquimod-Induced Psoriasiform Dermatitis through Inhibition of IL-17A Expression by Innate γδ-Low T Cells
(2015)
Notes:
HiP™ indicates a high purity protein with ≥90% purity as measured by gel filtration.
This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.Warning(s):
Avoid freeze/thaw cycles. Protein may be diluted to ≥ 100 μg/ml in PBS + glycerol and stored at -80°C.
Scientific Category:
Immunotherapy
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
