Bpsbioscience/PD-L1 (CD274), Fc fusion (Human) HiP™/71104-1/50 µg
商品编号：
71104-1
品牌：
bpsbioscience
市场价：
¥3980.00
美元价：
2388.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:HEK293
MW:52kDa
Genbank#:NM_014143
Tag(s):C-terminalFcfusion(HumanIgG1)
a.a:19–239
Background:
PD-L1isinvolvedinthecostimulatorysignalessentialforT-cellproliferationandproductionofIL-10andIFNgamma.InteractionwithPD-1inhibitsT-cellproliferationandcytokineproduction,anddown-regulatestheimmuneresponse.PD
Description:
HumansecretedProgrammedCellDeath1Ligand1(PD-L1)-Fcfusionprotein,alsoknownasCD274andB7homolog1(B7-H1),GenBankAccessionNo.NM_014143,aminoacids19-239,fusedattheC-terminustotheFcportionofhumanIgG1,expressedinaHEK293cellexpressionsystem.MW=52kDa.
UniProt
Q9NZQ7
Synonym(s):
ProgrammedCellDeath1Ligand1,PDL1,PD-L1,B7homolog1,B7H1,B7-H1,CD274,PDCD1L1
AssayConditions:
PD-L1bindingtoPD-1wastestedfollowingprotocolforBPSCat.#72005.Briefly,wellswerecoatedwith10ngofPD-L1inPD-1assaybuffer.VaryingconcentrationsofbiotinylatedPD-1wasaddedandwellswereincubatedatroomtemp.for2hoursbeforeaddingstrep-HRP,followedbychemiluminescentsubstrate.Luminescencewasreadonachemiluminescentplatereader.
Formulation:
8mMphosphate,pH7.4,110mMNaCl,2.2mMKCl,and20%glycerol
Format:
Aqueousbuffersolution
Storage/StABIlity:
Atleast6monthsat–80°C.
Application(s):
Usefulforthestudyofprotein-proteininteractionandinvitroandinvivoproteinfunction.
Reference(s):
1.Freeman,G.J.,etal.,JExpMed.2000Oct2;192(7):1027-34.
2.Dong,H.,etal.,NatMed.1999Dec;5(12):1365-9.
ApplicationReference(s):
CuttingEdge:PD-1RegulatesImiquimod-InducedPsoriasiformDermatitisthroughInhibitionofIL-17AExpressionbyInnateγδ-LowTCells(2015)
Notes:
HiP™indicatesahighpurityproteinwith≥90%purityasmeasuredbygelfiltration.
ThisproteinrunsatahigherM.W.bySDS-PAGEduetoglycosylation.Warning(s):
Avoidfreeze/thawcycles.Proteinmaybedilutedto≥100μg/mlinPBS+glycerolandstoredat-80°C.
ScientificCategory:
Immunotherapy
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
