Bpsbioscience/PCSK9, His-Avi-Tag (Mouse)/71221-1/20 µg
商品编号：
71221-1
品牌：
bpsbioscience
市场价：
¥5000.00
美元价：
3000.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Mouse
HostSpecies:HEK293cells
MW:74kDa
Genbank#:NM_153565
Tag(s):C-terminalHis-Avi-tag
a.a:35-694(end)
Background:
PCSK9isacrucialplayerintheregulationofplasmacholesterolhomeostasis.Itbindstolow-densitylipidreceptorfamilymembers:lowdensitylipoproteinreceptor(LDLR),verylowdensitylipoproteinreceptor(VLDLR),apolipoproteinEreceptor(LRP1/APOER)andapolipoproteinreceptor2(LRP8/APOER2),andpromotestheirdegradation.Actsviaanon-proteolyticmechanismtoenhancethedegradationofthehepaticLDLRthroughaclathrinLDLRAP1/ARH-mediatedpathway.MaypreventtherecyclingofLDLRfromendosomestothecellsurfaceordirectittolysosomesfordegradation.CaninduceubiquitinationofLDLRleADIngtoitssubsequentdegradation.InhibitsintracellulardegradationofAPOBviatheautophagosome/lysosomepathwayinaLDLR-independentmanner.Involvedinthedisposalofnon-acetylatedintermediatesofBACE1intheearlysecretorypathway.InhibitsepithelialNa(+)channel(ENaC)-mediatedNa(+)absorptionbyreducingENaCsurfaceexpressionprimarilybyincreasingitsproteasomaldegradation.RegulatesneuronalapoptosisviamodulationofLRP8/APOER2levelsandrelatedanti-apoptoticsignalingpathways.
Description:
Mouseproproteinconvertasesubtilisin/kexintype9(PCSK9),alsoknownasFH3,HCHOLA3,andPC9,GenBankAccessionNo.NM_153565,a.a.35-694(end),withC-terminalHis-Avi-tag,MW=74kDa(calculated),expressedinaHEK293cellexpressionsystem.
Synonym(s):
FH3,HCHOLA3,PC9,NARC1,NeuralApoptosisRegulatedConvertase1
Formulation:
40mMTris-HClpH8.0,110mMNaCl,2.2mMKCl,0.04%Tween20,and20%glycerol.
Storage/StABIlity:
Atleast6monthsat–80°C.Avoidfreeze/thawcycles.Storingdilutedproteinisnotrecommended,ifnecessary,usecarierprotein(BSA0.1–0.5%).
Application(s):
Usefulforstudyingproteinbindingandscreeningsmallmoleculesfordrugdiscovery.
Reference(s):
1.Abifadel,M.,etal.,NatGenet.2003Jun,34(2):154-6.
2.Abifadel,M.,etal.,HumMutat.2009Apr,30(4):520-9.
2.Abifadel,M.,etal.,HumMutat.2009Apr,30(4):520-9.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
CholesterolRelated
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
