Bpsbioscience/SGC-CBP30/27650-2/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Bpsbioscience/SGC-CBP30/27650-2/50 mg

Bpsbioscience/SGC-CBP30/27650-2/50 mg

商品编号： 27650-2

品牌： bpsbioscience

市场价： ¥11500.00

美元价： 6900.00

产地：美国(厂家直采)

公司：

产品分类：细胞因子

公司分类： cytokine

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

MW:509.0Da

Formula:C₂₈H_{33C_lN₄O₃Target:CREBBP,p300
Background:
CREBBP(CBP)andEP300aregeneraltranscriptionalco-activators,whichareinvolvedinmanyBIOLOGicalprocesseslikemaintenanceofgenomicstABIlitybyaffectingDNAreplicationandDNArepairaswellascellgrowth,transformationanddevelopment.Theyalsoplayandessentialroleinneuronalplasticity/memoryformationhematopoiesisandenergyhomeostasisasdemonstratedinavarietyofmousemodels.Theypossessbothacetyl-transferaseenzymaticandbromodomaincontainingregions.Throughacetylationofnon-histoneproteinsCREBBPcanhaveapositiveornegativeeffectontranscriptionalregulationbyaffectingprotein-proteininteractions,protein-DNAinteractions,nuclearretentionorproteinhalf-life.
Description:
PotentCREBBP/EP300bromodomaininhibitor
Synonym(s):
SGCCBP30;SGCCBP30;4-[(2S)-1-[2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]propan-2-yl]morpholine
Purity:
≥98%byHPLC
BiologicalActivity:
InhibitorofCREBBP/EP300bromodomains(IC50valuesare21-69and38nMforCREBBPandEP300bromodomains,respectively).Displaysover40-foldselectivityforCREBBPoverBRD4.AcceleratesFRAPrecoveryincellsataconcentrationof1µM.
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow+4°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.
Reference(s):
Gallenkampetal.(2014).ChemMedChem9:438.
ScientificCategory:
BromodomainInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.}

品牌介绍

bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。

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