Bpsbioscience/SGC-CBP30/27650-1/10 mg
商品编号：
27650-1
品牌：
bpsbioscience
市场价：
¥4400.00
美元价：
2640.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 509.0 Da
Formula: C28H33ClN4O3
Target: CREBBP, p300
Background:
CREBBP (CBP) and EP300 are general transcriptional co-activators, which are involved in many biological processes like maintenance of genomic stability by affecting DNA replication and DNA repair as well as cell growth, transformation and development. They also play and essential role in neuronal plasticity/ memory formation hematopoiesis and energy homeostasis as demonstrated in a variety of mouse models. They possess both acetyl-transferase enzymatic and bromodomain containing regions. Through acetylation of non-histone proteins CREBBP can have a positive or negative effect on transcriptional regulation by affecting protein- protein interactions, protein-DNA interactions, nuclear retention or protein half-life.
Description:
Potent CREBBP/EP300 bromodomain inhibitor
Synonym(s):
SGCCBP30; SGC CBP30; 4-[(2S)-1-[2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]propan-2-yl]morpholine
Purity:
≥98% by HPLC
Biological Activity:
Inhibitor of CREBBP/EP300 bromodomains (IC50 values are 21-69 and 38 nM for CREBBP and EP300 bromodomains, respectively). Displays over 40-fold selectivity for CREBBP over BRD4. Accelerates FRAP recovery in cells at a concentration of 1 µM.
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.
Reference(s):
Gallenkamp et al. (2014). Chem Med Chem 9:438.
Scientific Category:
Bromodomain Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
