Bpsbioscience/Anti-PCSK9 Neutralizing Antibody/71207/50 µg
商品编号：
71207
品牌：
bpsbioscience
市场价：
¥9800.00
美元价：
5880.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species: Human
Host Species: Freestyle 293 cells
MW: ~150 kDa
Tag(s): none
Clonality: Monoclonal (human)
Isotype: IgG1
Background:
PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a
clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
Description:
PCSK9 Neutralizing Antibody, a neutralizing recombinant human antibody (IgG1) recognizies the LDLR binding region of human PCSK9.
Synonym(s):
Anti-PCSK9
Assay Conditions:
3.8 ng/µl biotinylated PCSK9 was incubated with various concentrations of Anti-PCSK9 for 1 hr in a 50 µl reaction mix. Mixture was incubated on LDLR coated plate for 2 hr. Streptavidin labeled HRP was added and incubated for 1 hr. Finally, HRP chemiluminescent substrates were added and luminescence was read.
Formulation:
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Immunogen:
LDLR binding region of human PCSK9
Format:
Aqueous buffer solution
Storage / Stability:
>6 months at -80°C.
Application(s):
Useful as an inhibitor of PCSK9-LDLR binding using the PCSK9[Biotinylated]-LDLR Binding Assay Kit, Cat. #72002.
Reference(s):
1. Banerjee, Y., et al., N Engl J Med. 2012 Jun 21,366(25):2425-6.
2. Maxwell, K.N., Breslow, J.L., Circ Res. 2012 Jul 20,111(3):274-7.
Application Reference(s):
1. Cell-based, bioluminescent assay for monitoring the interaction between PCSK9 and the LDL receptor (2017)
2. PCSK9 is a critical regulator of the innate immune response and septic shock outcome (2014)
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Cholesterol-Related
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
