Bpsbioscience/WP1130/27722-2/25 mg
商品编号：
27722-2
品牌：
bpsbioscience
市场价：
¥4300.00
美元价：
2580.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:384.3Da
CASRegistry#:856243-80-6
Formula:C19H18BrN3O
Description:
Apartially-selective,cellpermeableDUBinhibitorthatdirectlyinhibitsUSP9x,USP5,USP14,andUCH37.WP1130,derivedfromthetyrphostinAG490,wasidentifiedinascreenformoleculesthatsuppressIL-3andIL-6activationofSTATmolecules.Ithasbeensubsequentlyshowntoinducerapidaccumulationofpolyubiquitinated(K48/K63-linked)proteinsintojuxtanuclearaggresomes,blockJAK2signalingthroughJAK2ubiquitinationandsubsequentdownregulation,andexhibitantiviralactivitythroughactivationoftheunfoldedproteinresponse(UPR).Typicalconcentrationforcellcultureexperimentsis5μM.
Synonym(s):
Degrasyn,(S,E)–3–(6–bromopyridin–2–yl)–2–cyano–N–(1–phenylbutyl)acrylamide
Purity:
≥98%byTLC.
Solubility:
SolubleinDMSO(45mg/ml);Ethanol(25mg/ml)
Format:
Paleyellowpowder
Application(s):
Suitableforcell-basedstudiesofUSPfunction.
Reference(s):
1.Kapuria,V.etal.Deubiquitinaseinhibitionbysmall-moleculeWP1130triggersaggresomeformationandtumorcellapoptosis.CancerRes.2010,70(22):9265
2.Batholomeusz,G.A.,etal.ActivationofanovelBcr/AbldestructionpathwaybyWP1130inducesapoptosisofchronicmyelogenousleukemiacells.Blood.2007109(8):3470.>br>3.Kapuria,V.etal.AnovelsmallmoleculedeubiquitinaseinhibitorblocksJak2signalingthroughJak2ubiquitination.Infect.Immun.2011,23(12):2076.
2.Batholomeusz,G.A.,etal.ActivationofanovelBcr/AbldestructionpathwaybyWP1130inducesapoptosisofchronicmyelogenousleukemiacells.Blood.2007109(8):3470.>br>3.Kapuria,V.etal.AnovelsmallmoleculedeubiquitinaseinhibitorblocksJak2signalingthroughJak2ubiquitination.Infect.Immun.2011,23(12):2076.
Warning(s):
Protectfrommoisture.
ScientificCategory:
UbiquitinEnzymes
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
