Bpsbioscience/SENP1 Core Domain, His-tag/81092/25 µg
商品编号：
81092
品牌：
bpsbioscience
市场价：
¥7000.00
美元价：
4200.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:28kDa
Tag(s):His-tag
Background:
SENP1isaSUMOisopeptidasethatplaysacriticalroleinthedevelopmentofprostatecancer.SENP1isoverexpressedinprostatecancersamplesandtransgenicoverexpressionofSENP1intheprostateofmiceleadstothedevelopmentofprostaticintraepithelialneoplasiaatanearlyage.Consistentwiththemodelstatedabove,investigatorshavedemonstratedthatoverexpressionofSENP1enhancesandrogen-receptormediatedtranscription.InactivationofSENP1inmicebyretroviralinsertionalmutationisembryoniclethal(e12.5-e14.5)andleadstoanincreaseinthesteady-statelevelsofSUMOylatedformsofanumberofproteins.DepletionofSENP1levelsinPC3cellsbyRNAileadstoadecreaseincyclinD1expression.TransgenicoverexpressionofSENP1intheprostateofmiceleadstoneoplasiaatanearlyage.AlloftheseexperimentsdemonstratethatSENP1playsacrucialroleinthegrowthanddevelopmentoforganisms.ReinforcingthepotentialroleSENP1mayplayinprostatecanceristheobservationthatSENP1isoverexpressedinmanyprostatecancersamples.
Description:
HumanSENP1CoreDomainrecombinantprotein,withHis-tag,expressedinE.coli.
UniProt
Q9P0U3
Synonym(s):
Sentrin/SUMO-specificproteaseSENP1,Sentrin-specificprotease1,SMT3specificpeptidase1
Format:
Aqueousbuffersolution
Storage/StABIlity:
Storeatorbelow–80°C.Stableassuppliedforupto1yearwhenstoreddessicatedat–80°C.
Application(s):
ThisenzymeisactiveintheSUMO3-CHOPassay.
Reference(s):
1.Cheng,J.,etal.,Roleofdesumoylationinthedevelopmentofprostatecancer.Neoplasia,2006.8(8):p.667-76.
2.Cheng,J.,etal.,SENP1enhancesandrogenreceptor-dependenttranscriptionthroughdesumoylationofhistonedeacetylase1.MolCellBiol,2004.24(13):p.6021-6028.
3.Yamaguchi,T.,etal.,MutationofSENP1/SuPr-2revealsanessentialrolefordesumoylationinmousedevelopment.MolCellBiol,2005.25(12):p.5171-82.
2.Cheng,J.,etal.,SENP1enhancesandrogenreceptor-dependenttranscriptionthroughdesumoylationofhistonedeacetylase1.MolCellBiol,2004.24(13):p.6021-6028.
3.Yamaguchi,T.,etal.,MutationofSENP1/SuPr-2revealsanessentialrolefordesumoylationinmousedevelopment.MolCellBiol,2005.25(12):p.5171-82.
Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
Ubiquitination(SUMOylation)
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
