Bpsbioscience/PYR-41/27716-1/10 mg
商品编号：
27716-1
品牌：
bpsbioscience
市场价：
¥4800.00
美元价：
2880.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:371.3Da
CASRegistry#:418805-02-4
Formula:C17H13N3O7
Description:
PYR-41isacellpermeable,irreversIBLeinhibitorofubiquitinactivatingenzymeE1withlittleornoactivityagainstE2sorE3s(IC50<10μM).Itblocksdegradationofp53andinhibitsNF-kappaB-dependentpathways.PYR-41alsoincreasesSUMOylationofproteins.
Synonym(s):
4–[4–[(5–Nitro–2–furanyl)methylene]?–3,5–dioxo–1–pyrazolidinyl]benzoicacidethylester
Purity:
>98%byTLC.
Solubility:
SolubleinDMSO(100mM)
Format:
Brownpowder
Storage/StABIlity:
Storeat+4°C.Stableassuppliedforupto2yearswhenstoreddessicatedat+4°C.Storesolutionsat-20°Cforupto1week.
Application(s):
UsefulforinhibitionofE1ubiquitinconjugatingenzymes
Reference(s):
1.Yangetal(2007).Inhibitorsofubiquitin-activatingenzyme(E1),anewclassofpotentialcancertherapeutics.CancerRes.67:9472.
2.Mietal(2009).Cancerpreventativeisothiocyanatesinduceselectivedegradationofcellular?-and?-tubulinsbyproteasomes.J.Biol.Chem.284:17039.
3.Brahemietal(2010).HomologymodellingofhumanE1ubiquitinactivatingenzyme.Lett.DrugDes.Discov.7:57.
2.Mietal(2009).Cancerpreventativeisothiocyanatesinduceselectivedegradationofcellular?-and?-tubulinsbyproteasomes.J.Biol.Chem.284:17039.
3.Brahemietal(2010).HomologymodellingofhumanE1ubiquitinactivatingenzyme.Lett.DrugDes.Discov.7:57.
Warning(s):
Protectfromlight.Protectfrommoisture.Avoidfreeze/thawcycles.
ScientificCategory:
UbiquitinEnzymes
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
