Bpsbioscience/PS-341（MG-341）/27715-1/25毫克
商品编号：
27715-1
品牌：
bpsbioscience
市场价：
¥10600.00
美元价：
6360.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:384.2Da
CASRegistry#:179324-69-7
Formula:C19H25BN4O4
Description:
PS-341(Pyz-Phe-boroLeu)istheactiveingredientinBortezomib.PS-341isareversIBLe,cellpermeable,potent,andselectiveproteasomeinhibitor(Ki=0.6nM).Itbindsthecatalyticsiteofthe26Sproteasomewithhighaffinityandspecificity.Inhibitsproliferationofanumberoftumorcelllines(IC50=7nM).InhibitsTNFsynthesisandFGF-inducedangiogenesis.
Synonym(s):
Pyz–Phe–boroLeu,N–(2–pyrazine)carbonyl–L–phenylalanyl–L–leucylboronicacid
Purity:
>98%byHPLC.
Solubility:
SolubleinDMSO
Format:
Whitepowder
Storage/StABIlity:
Storeat+4°C.Stableassuppliedforupto2yearswhenstoreddessicatedat+4°C.Storesolutionsat-20°Cforupto1week.
Application(s):
Usefulforasapotent,cellpermeableproteasomeinhibitorfordrugdiscoveryresearch.
Reference(s):
1.Yi-HeLingetall.PS-341,aNovelProteasomeInhibitor,InducesBcl-2PhosphorylationandCleavageinAssociationwithG2-MPhaseArrestandApoptosis.MolCancerTher.2002;1:841-849.
2.AdamsJ.DevelopmentoftheProteasomeInhibitorPS-341.TheOncologist2002;7:9-16.
.DudekSAetal.TheclinicallyapprovedproteasomeinhibitorPS-341efficientlyblocksinfluenzaAvirusandvesicularstomatitisviruspropagationbyestablishinganantiviralstate.JVirol.2010Sep;84:9439-51.
2.AdamsJ.DevelopmentoftheProteasomeInhibitorPS-341.TheOncologist2002;7:9-16.
.DudekSAetal.TheclinicallyapprovedproteasomeinhibitorPS-341efficientlyblocksinfluenzaAvirusandvesicularstomatitisviruspropagationbyestablishinganantiviralstate.JVirol.2010Sep;84:9439-51.
Warning(s):
Protectfrommoisture.Avoidfreeze/thawcycles.
ScientificCategory:
UbiquitinEnzymes
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
