Bpsbioscience/PS-341（MG-341）/27715-2/5毫克
商品编号：
27715-2
品牌：
bpsbioscience
市场价：
¥6300.00
美元价：
3780.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 384.2 Da
CAS Registry #: 179324-69-7
Formula: C19H25BN4O4
Description:
PS-341 (Pyz-Phe-boroLeu) is the active ingredient in Bortezomib. PS-341 is a reversible, cell permeable, potent, and selective proteasome inhibitor (Ki=0.6 nM). It binds the catalytic site of the 26S proteasome with high affinity and specificity. Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis.
Synonym(s):
Pyz–Phe–boroLeu, N–(2–pyrazine)carbonyl–L–phenylalanyl–L–leucyl boronic acid
Purity:
>98% by HPLC.
Solubility:
Soluble in DMSO
Format:
White powder
Storage / Stability:
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.
Application(s):
Useful for as a potent, cell permeable proteasome inhibitor for drug discovery research.
Reference(s):
1. Yi-He Ling et all. PS-341, a Novel Proteasome Inhibitor, Induces Bcl-2 Phosphorylation and Cleavage in Association with G2-M Phase Arrest and Apoptosis. Mol Cancer Ther. 2002; 1:841-849.
2. Adams J. Development of the Proteasome Inhibitor PS-341. The Oncologist 2002; 7:9-16.
. Dudek SA et al. The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state. J Virol. 2010 Sep;84:9439-51.
2. Adams J. Development of the Proteasome Inhibitor PS-341. The Oncologist 2002; 7:9-16.
. Dudek SA et al. The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state. J Virol. 2010 Sep;84:9439-51.
Warning(s):
Protect from moisture. Avoid freeze/thaw cycles.
Scientific Category:
Ubiquitin Enzymes
Product Type:
Inhibitors/Activators
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
