Bpsbioscience/P22077/27712-1/10 mg
商品编号：
27712-1
品牌：
bpsbioscience
市场价：
¥4700.00
美元价：
2820.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:315.3Da
CASRegistry#:1247819-59-5
Formula:C12H7F2NO3S2
Description:
P22077isacellpermeableinhibitoroftheubiquitin-specificproteaseUSP7(IC50=8.6µM),andthecloselyrelateddeubiquitinase(DUB)USP47.P22077showedweakornoinhibition(EC50>50µM)towardsapanelof14isopeptidasesandotherproteases.TreatmentofcellswithP22077(20–40µM)causesanaccumulationofK48-linkedubiquitinatedspecies,anddownregulationoftheUSP7targetsHDM2andclaspin.
Synonym(s):
Ethanone,1–[5–[(2,4–difluorophenyl)thio]–4–nitro–2–thienyl]–
Purity:
≥98%byHPLC.
Solubility:
SolubleinDMSO
Format:
Lightpowder
Storage/StABIlity:
Storeat+4°C.Stableassuppliedforupto2yearswhenstoreddessicatedat+4°C.Storesolutionsat-20°Cforupto1month.
Application(s):
UsefulforinhibitionofUSP7andUSP47activity.
Reference(s):
1.Altun,M.,etal.,Activity-basedchemicalproteomicsacceleratesinhibitordevelopmentfordeubiquitylatingenzymes.ChemBiol,2011.18(11):p.1401-12.
2.Tian,X.,etal.,Characterizationofselectiveubiquitinandubiquitin-likeproteaseinhibitorsusingafluorescence-basedmultiplexassayformat.AssayDrugDevTechnol,2011.9(2):p.165-73.
2.Tian,X.,etal.,Characterizationofselectiveubiquitinandubiquitin-likeproteaseinhibitorsusingafluorescence-basedmultiplexassayformat.AssayDrugDevTechnol,2011.9(2):p.165-73.
Warning(s):
Protectfrommoisture.
ScientificCategory:
UbiquitinEnzymes
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
