Bpsbioscience/P005091/27767-2/50 mg
商品编号：
27767-2
品牌：
bpsbioscience
市场价：
¥6600.00
美元价：
3960.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 348.2 Da
CAS Registry #: 882257-11-6
Formula: C12H7Cl2NO3S2
Target: USP7
Background:
USP7, known as herpes-associated-ubiquitin-specificprotease (HAUSP), is a deubiquitylating enzyme that regulates the levels of the oncoprotein HDM2 and its substrate, the tumor suppressor p53. P005091 accelerated the degradation of HDM2, while analogs of the compound induced dose- and time-dependent increases in the protein levels of p53 and p21. P005091 induced apoptosis in numerous cancer cell lines, including both p53+/+ and p53-mutant cancer cell lines. P005091 also downregulated claspin and phosphorylation of the DNA checkpoint kinase Chk1.
Description:
P005091 is a selective, potent inhibitor of USP7 deubiquitylating activity.
Synonym(s):
P005091; P5091
Biological Activity:
Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 µM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity on USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.
Scientific Category:
Deubiquitinase Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
