Bpsbioscience/P005091/27767-1/10 mg
商品编号：
27767-1
品牌：
bpsbioscience
市场价：
¥2900.00
美元价：
1740.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:348.2Da
Background:
USP7,knownasherpes-associated-ubiquitin-specificprotease(HAUSP),isadeubiquitylatingenzymethatregulatesthelevelsoftheoncoproteinHDM2anditssubstrate,thetumorsuppressorp53.P005091acceleratedthedegradationofHDM2,whileanalogsofthecompoundinduceddose-andtime-dependentincreasesintheproteinlevelsofp53andp21.P005091inducedapoptosisinnumerouscancercelllines,includingbothp53+/+andp53-mutantcancercelllines.P005091alsodownregulatedclaspinandphosphorylationoftheDNAcheckpointkinaseChk1.
Description:
P005091isaselective,potentinhibitorofUSP7deubiquitylatingactivity.
Synonym(s):
P005091;P5091
BIOLOGicalActivity:
Selectiveinhibitorofubiquitin-specificprotease(USP)7(IC50=4.2µM).Displayslittle-to-noinhibitionofotherUSPvariantsorproteasessuchascaspase,cathepsinsandserineproteases;exhibitssomeactivityonUSP47.Induceselevatedp53andapoptosisincancercelllines;displaysantiangiogenicactivityinvivo.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow+4°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.
ScientificCategory:
DeubiquitinaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
