Bpsbioscience/NSC697923/27765-2/25 mg
商品编号：
27765-2
品牌：
bpsbioscience
市场价：
¥3600.00
美元价：
2160.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:267.3Da
CASRegistry#:343351-67-7
Formula:C11H9NO5S
Target:Ubc13-Uev1A
Background:
NSC697923selectivelyinhibitsPMA-inducedNF-?Bactivation,andalsoinhibitsI?BαphosphorylationbybothRANKLandLPS.NSC697923impedestheformationoftheUbc13andubiquitinthioesterconjugateandsuppressesconstitutiveNF-?BactivityinABC-DLBCLcells.Inaddition,NSC697923inhibitstheproliferationandsurvivalofABC-DLBCLcellsandGCB-DLBCLcells,andalsoinducesapoptosisofprimaryDLBCLcells.Inneuroblastoma(NB)celllines,NSC697923showscytotoxiceffect,andinhibitsbothanchorage-dependentand-independentcolonyformation.
Description:
NSC697923isacell-permeableandselectiveinhibitoroftheUb-conjugatingenzyme(E2)complexUbc13-Uev1A.ItisbelievedtoactbydisruptingformationoftheUbc13:Ubconjugate.ShowntoinhibitproliferationandsurvivalofcertainB-celllymphomacells.
Synonym(s):
2-(4-Methylphenyl)sulfonyl-5-nitrofuran
BIOLOGicalActivity:
SelectivelyinhibitstheE2Ubiquitin-conjugatingenzymeUbc13-,butnotUbcH5c-,catalyzedK63-linkedpolyUbchainformationbypreventingUbc13-Ubthioesterbondformation.EffectivelyinhibitsUbc13-Uev1A(UBE2V1)E2complex-mediatedNF-?Bactivation,Ubc13-Mms2(UBEV2)E2complex-mediatedDNADSB(double-strandbreak)repairactivation,aswellasUbc13-dependentp53nuclearexportincultures(1to2µM).ThecombinedNF-?Binhibitionandp53activationviaUbc13inhibitionisshowntobeparticularlyeffectiveagainsttheproliferationofABC(ActivatedB-cell-like)andGCB(GerminalcenterB-cell-like)DLBCL(DiffuseLargeB-CellLymphoma)celllinesandprimaryDLBCLculturesviaapoptosisinduction(1to2µM).
Solubility:
SolubleinDMSO(20mg/ml).
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Pulvino,M.,etal.2012.Blood120:1668-1677
ScientificCategory:
E2conjugating
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
