Bpsbioscience/MLN-4924/27708/1 mg
商品编号：
27708
品牌：
bpsbioscience
市场价：
¥6100.00
美元价：
3660.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:443.2Da
CASRegistry#:905579-51-3
Formula:C21H25N5O4S
Description:
ContainingtheactiveingredientofMLN4924whichactsasasubstrate-assistedinhibitoroftheNEDD8-activatingenzyme(NAE).NAEactivatesNEDD8(Neuralprecursorcellexpressed,developmentallydown-regulated8)forconjugationtoavarietyofubiquitinE3ligases.NAEinhibitorbindstoandinhibitsNAE,whichmayresultintheinhibitionoftumorcellproliferationandsurvival.ThiscellpermeablecompoundselectivelyinhibitsNAEactivityandresultsininhibitionoftheNEDD8pathway.TreatmentofcellswithMLN4924resultsininhibitionoftheNEDD8pathway,makingMLN4924anewapproachtotargetingtheUPSforthetreatmentofcancer.
Synonym(s):
NEDD8–activatingenzymeinhibitor
Purity:
≥98%
Solubility:
SolubleinDMSO(10mg/ml)
Format:
Whitepowder
Application(s):
UsefulforinhibitionoftheNEDD8andNEDD8-dependentpathways.
Reference(s):
1.Brownell,J.E.etal.Substrate-assistedinhibitionofubiquitin-likeprotein-activatingenzymes:theNEDD8E1inhibitorMLN4924formsaNEDD8-AMPmimeticinsitu.MolecularCell2010.37:102-111.
2.Milhollen,M.A.etal.MLN4924,aNEDD8-activatingenzymeinhibitor,isactiveindiffuselargeB-celllymphomamodels:rationalefortreatmentofNF-kB-dependentlymphoma.Blood,2010.116:1515-1523.
2.Milhollen,M.A.etal.MLN4924,aNEDD8-activatingenzymeinhibitor,isactiveindiffuselargeB-celllymphomamodels:rationalefortreatmentofNF-kB-dependentlymphoma.Blood,2010.116:1515-1523.
Warning(s):
Protectfrommoisture.
ScientificCategory:
UbiquitinEnzymes
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
