Bpsbioscience/PYR-41/27716-3/50毫克
商品编号：
27716-3
品牌：
bpsbioscience
市场价：
¥8800.00
美元价：
5280.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 371.3 Da
CAS Registry #: 418805-02-4
Formula: C17H13N3O7
Description:
PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 μM). It blocks degradation of p53 and inhibits NF-kappaB-dependent pathways. PYR-41 also increases SUMOylation of proteins.
Synonym(s):
4–[4–[(5–Nitro–2–furanyl)methylene]?–3,5–dioxo–1–pyrazolidinyl]benzoic acid ethyl ester
Purity:
>98% by TLC.
Solubility:
Soluble in DMSO (100 mM)
Format:
Brown powder
Storage / Stability:
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.
Application(s):
Useful for inhibition of E1 ubiquitin conjugating enzymes
Reference(s):
1. Yang et al (2007). Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res. 67:9472.
2. Mi et al (2009). Cancer preventative isothiocyanates induce selective degradation of cellular ?- and ?-tubulins by proteasomes. J. Biol. Chem. 284:17039.
3. Brahemi et al (2010). Homology modelling of human E1 ubiquitin activating enzyme. Lett. Drug Des. Discov. 7:57.
2. Mi et al (2009). Cancer preventative isothiocyanates induce selective degradation of cellular ?- and ?-tubulins by proteasomes. J. Biol. Chem. 284:17039.
3. Brahemi et al (2010). Homology modelling of human E1 ubiquitin activating enzyme. Lett. Drug Des. Discov. 7:57.
Warning(s):
Protect from light. Protect from moisture. Avoid freeze/thaw cycles.
Scientific Category:
Protease
Product Type:
Inhibitors/Activators
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
