Bpsbioscience/P22077/27712-2/50 mg
商品编号：
27712-2
品牌：
bpsbioscience
市场价：
¥9900.00
美元价：
5940.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 315.3 Da
CAS Registry #: 1247819-59-5
Formula: C12H7F2NO3S2
Description:
P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7 (IC50=8.6 µM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 >50µM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20–40 µM) causes an accumulation of K48-linked ubiquitinated species, and down regulation of the USP7 targets HDM2 and claspin.
Synonym(s):
Ethanone, 1–[5–[(2,4–difluorophenyl)thio]–4–nitro–2–thienyl]–
Purity:
≥98% by HPLC.
Solubility:
Soluble in DMSO
Format:
Light powder
Storage / Stability:
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.
Application(s):
Useful for inhibition of USP7 and USP47 activity.
Reference(s):
1. Altun, M., et al. , Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem Biol, 2011. 18(11): p. 1401-12.
2. Tian, X., et al., Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format. Assay Drug Dev Technol, 2011. 9(2): p. 165-73.
2. Tian, X., et al., Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format. Assay Drug Dev Technol, 2011. 9(2): p. 165-73.
Warning(s):
Protect from moisture.
Scientific Category:
Protease
Product Type:
Inhibitors/Activators
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
