Bpsbioscience/Obatoclax/27044/5 mg
商品编号：
27044
品牌：
bpsbioscience
市场价：
¥2400.00
美元价：
1440.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:413.5Da
CASRegistry#:803712-79-0
Formula:C20H19N3O•CH4SO3
Description:
Obatoclax,alsoknownasGX15-070,isanovelBcl-2homologydomain-3(BH3)mimetic.ItoccupiesahydrophobiccleftwithintheBH3bindinggrooveofBcl-2,antagonizingBcl-2andthusinducingapoptosis.Obatoclaxinhibitedprimaryacutemyeloidleukemia(AML)ProgenitorcellproliferationwithanaverageIC50of0.18±0.07µM,anditpotentlyinducedapoptosisinprimaryAMLcellswithanaverageIC50of3.6±1.2µM.ObatoclaxovercomesBcl-2-,Bcl-xL-,Bcl-w-,andMcl-1-mediatedresistancetoBAXorBAKandtotheproteasomeinhibitorbortezomib.
Synonym(s):
GX15-070,Obatoclaxmesylate
Purity:
≥99%
Solubility:
SolubleinDMSOat5mg/ml;verypoorlysolubleinethanol;verypoorlysolubleinwater;maximumsolubilityinplainwaterisestimatedtobeabout200-400µM
Format:
Brownpowder
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Chonghaile,T.N.andLetai,A.Oncogene27:S149-S157(2008).
2.Konopleva,M.,etal.CancerRes.68:3413-3420(2008).
3.Nguyen,M.,etal.Proc.Natl.Acad.Sci.USA104:19512-19517(2007).
2.Konopleva,M.,etal.CancerRes.68:3413-3420(2008).
3.Nguyen,M.,etal.Proc.Natl.Acad.Sci.USA104:19512-19517(2007).
ScientificCategory:
Apoptosis
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
